Gene description for Hgs
Gene name	HGF-regulated tyrosine kinase substrate
Gene symbol	Hgs
Other names/aliases	Hgr Hrs ZFYVE8 tn
Species	Mus musculus
Experiment description of studies that identified Hgs in Melanoma cells
1 Experiment ID 1169 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 29907695    Organism Mus musculus Experiment description Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles. Authors Steenbeek SC, Pham TV, de Ligt J, Zomer A, Knol JC, Piersma SR, Schelfhorst T, Huisjes R, Schiffelers RM, Cuppen E, Jimenez CR, van Rheenen J. Journal name EMBO J. Publication year 2018 Sample Melanoma cells Sample name B16F1 (100 K) Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein miRNA Methods used in the study Mass spectrometry RNA sequencing EV-TRACK -
2 Experiment ID 2981 Identified molecule protein Extracellular vesicle type Exosomes MISEV Small EVs Identification method Western blotting PubMed ID 30089911    Organism Mus musculus Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response Authors Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W. Journal name Nature Publication year 2018 Sample Melanoma cells Sample name B16-F10 Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
3 Experiment ID 2982 Identified molecule protein Extracellular vesicle type Microvesicles MISEV Large EVs Identification method Western blotting PubMed ID 30089911    Organism Mus musculus Experiment description Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response Authors Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W. Journal name Nature Publication year 2018 Sample Melanoma cells Sample name B16-F10 - 16.5k pellet Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -